Bioinformatics Mcqs

Q:

Which of the following is false about the ‘loop’ structure in proteins?

A) They connect helices and sheets B) They are more tolerant of mutations
C) They are more flexible and can adopt multiple conformations D) They are never the components of active sites
 
Answer & Explanation Answer: D) They are never the components of active sites

Explanation: Loops are frequently components of active sites as they are flexible in nature and as they are situated on the surface of the structure. Besides, they vary in length and 3-D configurations which give even more chances to be component of active sites.

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Q:

On average, what is the length of a typical domain?

A) About 100 residues B) About 300 residues
C) About 500 residues D) About 900 residues
 
Answer & Explanation Answer: A) About 100 residues

Explanation: The predicted optimal number of residues, which corresponds to the maximum free energy of unfolding, is 100. This is in agreement with a statistical analysis derived from their experimental structures of motifs. For too short chain, change in enthalpy of internal interactions is not favorable enough for folding because of the limited number of inter-residue contacts. And a long chain is also unfavorable for a single domain.

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Q:

What is the length of a motif, in terms of amino acids residue?

A) 30- 60 B) 10- 20
C) 70- 90 D) 1- 10
 
Answer & Explanation Answer: B) 10- 20

Explanation: A typical motif is 10-20 amino acids long. For e.g. Zn-finger motif. Hence it is also referred to as super secondary structure. This motif is seen in transcription factors.

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